Using email aliases with different domains can significantly impact email deliverability and domain reputation. Mailbox providers may not be aware of the alias domain, potentially causing authentication issues. A poor reputation of the alias domain can negatively affect the primary domain's deliverability. Proper authentication of both the primary and alias domains using SPF, DKIM, and DMARC is crucial. Different domain aliases can dilute the sender score if not properly authenticated, necessitating alignment of authentication protocols across all aliases. Aliases with low-reputation domains can cause emails to land in spam folders. DMARC policies must be correctly configured for all domains, including aliases, to prevent spoofing and ensure legitimate emails are delivered. Monitoring the sender reputation of each domain alias separately is essential to prevent negative impacts. Tracking the health of each domain/email is important, as multiple aliases can affect deliverability. Essentially, without proper configuration and monitoring, email aliases with different domains can harm your overall email deliverability and sender reputation.