To resolve high bounce rates and 'mailbox unavailable' errors for a specific domain, experts and documentation recommend a multi-faceted approach centered on diligent list hygiene. The foundational step involves promptly ceasing mailings to problematic addresses and removing invalid email addresses identified by 'mailbox unavailable' errors, as these indicate non-existent recipients. Email verification tools are essential for validating addresses, and regular list cleaning is crucial. Employing double opt-in and preference centers helps prevent future bounces. If bounces are domain-specific, contacting the IT department of that domain is advised. Standardized bounce messages and codes should be analyzed for insights. Aim for a bounce rate below 2%. Re-engagement campaigns can salvage potentially valid addresses, but a risk-benefit analysis is critical before continuing mailings to questionable addresses, considering the impact on sender reputation and deliverability.